phone: (787) 832-4040 ext. 2297
fax: (787) 265-3849
email: aikomari.guzman@upr.edu
office: Q-372F
website:
Group Members:

Ph.D. University of California, San Diego, 2007

National Institute of Health Postdoctoral Fellowship (May 2008 - May 2010)

Organic chemistry

Developing chemical synthesis of bioactive molecules for biological research.

To discover new concepts in synthetic organic chemistry involving metal-mediated or metal-free catalysis for the ease of total synthesis of natural products and pharmaceuticals.

1. Guzman-Martinez, A.; Hoveyda, A. H. "Enantioselective Synthesis of Allylboronates Bearing a Tertiary or Quaternary B-Substituted Stereogenic Carbon by NHC-Cu-Catalyzed Substitution Reactions" J. Am. Chem. Soc., 2010, 132, 10634-10637.
    
2. Guzman-Martinez, A.; Lamer, R. B.; VanNieuwenhze, M. S.; "Total Synthesis of Lysobactin", J. Am. Chem. Soc., 2007, 129, 6017-6021.
    
3. Guzman-Martinez, A.; VanNieuwenhze, M. S.; Synlett, 2007, No. 10, 1513-1516.
    
4. Brown, M. F.* Bahnck, K. B.; Blumberg, L. C.; Brissette, W. H.; Burrell, S. A.; Driscoll, J. P.; Fedeles, F.; Fisher, M. B.; Foti, R. S.; Gladue, R. P.; Guzman-Martinez, A.; Hayward, M. M.; Lira, P. D.; Lillie, B. M.; Lu, Y.; Lundquist, G. D.; McElroy, E. B.; McGlynn, M. A.; Paradis, T. J.; Poss, C. S.; Roache, J. H.; Shavnya, A.; Shepard, R. M.; Trevena K. A.; and Tylaska, L. A.; "Piperazinyl CCR1 antagonists-optimization of human liver microsome stability", Bioorg. Med. Chem. Letters, 2007, 17, 3109-3112.